Development of a Method for Scaffold-Free Elastic Cartilage Creation

bovine articular cartilage decellularized matrix as a scaffold for use in cartilage tissue engineering

extracelllar matrix (ecm) materials from mammalian tissues have been broadly used for tissue engineering for animal models. while decellularization of tissues such as bladder, heart valve, knee meniscus and tendon has been performed, there are a few reports for articular cartilage. in this study we aimed to develop a technique to decellularize bovine articular cartilage as a biological construc...

Decellularized Cartilage as a Scaffold for Tissue Engineered Cartilage

Bioengineering Human Scaffold-free Cartilage Constructs Using Paediatric Auricular Tissue

Currently, patients with external ear deformities rely on hyaline cartilage grafts or silicone prosthesis to provide them with adequate external ear reconstruction. Scaffold-free auricular tissue engineering provides a means of creating patient specific cartilage constructs solely using their own cells, ensuring biocompatibility, long term stability, and reduced morbidity. Here, we have develop...

A Novel Through-Thickness Perfusion Bioreactor for the Generation of Scaffold-Free Tissue Engineered Cartilage

The objective of this study was to characterize our designed through-thickness perfusion bioreactor which could generate large scaffold-free tissue engineered cartilage constructs. The hypothesis being that through-thickness perfusion could accelerate maturation of scaffold-free tissue engineered cartilage, grown in transwell culture inserts large enough to repair typical size chondral lesions ...

Static and Free Vibration Analyses of Orthotropic FGM Plates Resting on Two-Parameter Elastic Foundation by a Mesh-Free Method

In this paper, static and free vibrations behaviors of the orthotropic functionally graded material (FGM) plates resting on the two-parameter elastic foundation are analyzed by the a mesh-free method based on the first order shear deformation plate theory (FSDT). The mesh-free method is based on moving least squares (MLS) shape functions and essential boundary conditions are imposed by transfer...